Cart
sales@molnova.com
JC124
CAS No. 1638611-48-9
JC124( —— )
Catalog No. M34086 CAS No. 1638611-48-9
JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
|
| 5MG | 141 | In Stock |
|
| 10MG | 226 | In Stock |
|
| 25MG | 378 | In Stock |
|
| 50MG | 527 | In Stock |
|
| 100MG | 714 | In Stock |
|
| 200MG | 918 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameJC124
-
NoteResearch use only, not for human use.
-
Brief DescriptionJC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.
-
DescriptionJC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.
-
In VitroJC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro.
-
In VivoJC124 (100?mg/kg; i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1.Animal Model:Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI) Dosage:100?mg/kg Administration:i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI Result:Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume.
-
Synonyms——
-
PathwayNF-κB
-
TargetNOD
-
RecptorNOD
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1638611-48-9
-
Formula Weight382.86
-
Molecular FormulaC17H19ClN2O4S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (652.98 mM; Ultrasonic; (HCL ，pH≈3); )
-
SMILESCNS(=O)(=O)c1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ram Kuwar, et al. A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury. J Neuroinflammation. 2019 Apr 11;16(1):81.?
molnova catalog
related products
-
JC-171
JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM.
-
NLRP3 agonist 1
NLRP3 agonist 1 (compound 23) is a potent, orally active agent that activates Caspase-1 enzyme, resulting in the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms .
-
ADS032
ADS032 (BT-032) is an NLRP1 and NLRP3 inhibitor with anti-inflammatory activity,, inhibits the activation of NLRP1 and NLRP3, inhibits Nigericin-induced IL-1β production, and can be used to study respiratory inflammation or infection.
