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SP-100030
CAS No. 154563-54-9
SP-100030( —— )
Catalog No. M34032 CAS No. 154563-54-9
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | Get Quote |
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| 5MG | 64 | Get Quote |
|
| 10MG | 101 | Get Quote |
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| 25MG | 235 | Get Quote |
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| 50MG | 365 | Get Quote |
|
| 100MG | 514 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSP-100030
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NoteResearch use only, not for human use.
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Brief DescriptionSP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both.
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DescriptionSP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA).
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In Vitro——
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In VivoAnimal Model:Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen) Dosage:10 mg/kg Administration:I.p.; daily, starting at day 21 to the end of the study on day 34 Result:Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation.
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Synonyms——
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number154563-54-9
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Formula Weight437.65
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Molecular FormulaC14H5ClF9N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (114.25 mM; Ultrasonic )
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SMILESC(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(=O)C=2C(C(F)(F)F)=NC(Cl)=NC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sullivan RW, et al. 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem. 1998;41(4):413-419.?
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