J-104871

CAS No. 191088-19-4

J-104871( —— )

Catalog No. M33992 CAS No. 191088-19-4

J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 296 Get Quote
5MG 459 Get Quote
10MG 657 Get Quote
25MG 994 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    J-104871
  • Note
    Research use only, not for human use.
  • Brief Description
    J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.
  • Description
    J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    Ras
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    191088-19-4
  • Formula Weight
    708.67
  • Molecular Formula
    C38H32N2O12
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(O)(=O)C1(C(O)=O)O[C@H](C(N([C@@H]([C@H](C/C=C/C2=NC=3C(O2)=CC=CC3)C=4C=C5C(=CC4)OCO5)C)CC6=CC7=C(C=C6)C=CC=C7)=O)[C@H](C(O)=O)O1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
related products
  • 1588-A4

    1588-A4 is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.

  • KRas-IN-1

    A chemical fragment hit that binds to K-Ras (G12D) with affinities of 1.3-2 mM.

  • PDE6δ inhibitor 8

    A novel selective small molecule inhibitor of PDE6δ/KRas interaction with Kd of 358 pM.