Fusarochromanone

Research use only, not for human use.

Fusarochromanone (FC-101) is a mycotoxin produced by Fusarium marcescens with potent antiangiogenic, anticancer and antimalarial activities.

Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity. Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS).

Fusarochromanone (FC101; 10 μM; 24 hours) induces apoptosis and an increase in proportion of cells in the sub-G1 phase in both HaCat and P9-WT cell lines. Fusarochromanone (FC101; 0-1 μM; 24 h) induces the cleavage of both caspase-3 and PARP, a well-known substrate for activated caspases. FC101 does not affect the expression of the anti-apoptotic proteins, Bcl-2, Bcl-XL, Mcl-1, or the pro-apoptotic proteins BAD, BAK, BAX.Fusarochromanone (FC101) exhibits very potent in-vitro growth inhibitory effects (IC50 ranging from 10 nM-2.5 μM) against HaCat (pre-malignant skin), P9-WT (malignant skin), MCF-7 (low malignant breast), MDA-231 (malignant breast), SV-HUC (premalignant bladder), UM-UC14 (malignant bladder), and PC3 (malignant prostate) in a time-course and dose-dependent manner, with the UM-UC14 cells being the most sensitive.Cell Cycle Analysis Cell Line:HaCat and P9-WT cell lines Concentration:10 μM Incubation Time:24 hours Result:Showed cells in the G2 and M phases of the cell cycle for both cell lines.Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:0.05 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM Incubation Time:24 hours Result:Induced the cleavage of both caspase-3 and PARP.

Fusarochromanone (8 mg/kg; IP; 5 days per week; for 3.5 weeks) Is well tolerated, non-toxic, and achieved a 30% reduction in tumor size at a dose of 8 mg/kg/day.Animal Model:SCID Beige mice (CB17/Icr.Cg-PrkdcscidLystbg/Crl) injected with SRB12-p9 cells Dosage:8 mg/kg Administration:IP; 5 days per week; for 3.5 weeks Result:Achieved a 30% reduction in tumor size at a dose of 8 mg/kg/day.

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Others

Other Targets

Reactive Oxygen Species

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802915-53-3

292.33

C15H20N2O4

>98% (HPLC)

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NC1=C2C(=CC=C1C(C[C@H](CO)N)=O)OC(C)(C)CC2=O

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(-20℃)

With Ice Pack

≥ 2 years