CAY10444( —— )

Catalog No. M33970 CAS No. 298186-80-8

CAY10444 is an S1P3 specific antagonist.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	41	In Stock
5MG	37	In Stock
10MG	65	In Stock
25MG	140	In Stock
50MG	230	In Stock
100MG	384	In Stock
200MG	522	In Stock
500MG	821	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

CAY10444
Note

Research use only, not for human use.
Brief Description

CAY10444 is an S1P3 specific antagonist.
Description

CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors.
In Vitro

BML-241 inhibits increases in intracellular Ca2+ concentration via P2 receptor or α1A-adrenoceptor stimulation and α1A-adrenoceptor-mediated contraction of rat mesenteric artery, while it does not affect S1P3-mediated decrease of Forskolin-induced cyclic AMP accumulation.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

298186-80-8
Formula Weight

287.46
Molecular Formula

C15H29NO2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 41.67 mg/mL (144.96 mM; Ultrasonic (<80°C)
SMILES

CCCCCCCCCCCC1N[C@@H](CS1)C(O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Salvatore Salomone, et al. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9. ?

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