VU 0285683( —— )

Catalog No. M33945 CAS No. 327056-22-4

VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	62	In Stock
2MG	33	In Stock
5MG	55	In Stock
10MG	68	In Stock
25MG	115	In Stock
50MG	161	In Stock
100MG	230	In Stock
200MG	312	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

VU 0285683
Note

Research use only, not for human use.
Brief Description

VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.
Description

VU0285683 is a selective mGluR5 positive allosteric modulator (PAM).VU0285683 has anxiolytic-like activity in rodent models for anxiety.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Neuroscience
Target

GluR
Recptor

GluR
Research Area

——
Indication

——

Chemical Information

CAS Number

327056-22-4
Formula Weight

266.23
Molecular Formula

C14H7FN4O
Purity

>98% (HPLC)
Solubility

——
SMILES

C(#N)C=1C=C(C=C(F)C1)C2=NC(=NO2)C3=CC=CC=N3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. ?

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