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VU 0285683
CAS No. 327056-22-4
VU 0285683( —— )
Catalog No. M33945 CAS No. 327056-22-4
VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 68 | In Stock |
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| 25MG | 115 | In Stock |
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| 50MG | 161 | In Stock |
|
| 100MG | 230 | In Stock |
|
| 200MG | 312 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU 0285683
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NoteResearch use only, not for human use.
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Brief DescriptionVU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.
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DescriptionVU0285683 is a selective mGluR5 positive allosteric modulator (PAM).VU0285683 has anxiolytic-like activity in rodent models for anxiety.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptorGluR
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Research Area——
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Indication——
Chemical Information
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CAS Number327056-22-4
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Formula Weight266.23
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Molecular FormulaC14H7FN4O
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Purity>98% (HPLC)
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Solubility——
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SMILESC(#N)C=1C=C(C=C(F)C1)C2=NC(=NO2)C3=CC=CC=N3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. ?
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