Cart
sales@molnova.com
Licostinel
CAS No. 153504-81-5
Licostinel( ACEA-1021 | ACEA 1021 | ACEA1021 | CGP-63446 | CGP 63446 )
Catalog No. M27895 CAS No. 153504-81-5
Licostinel is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | Get Quote |
|
| 10MG | 78 | Get Quote |
|
| 25MG | 165 | Get Quote |
|
| 50MG | 267 | Get Quote |
|
| 100MG | 399 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLicostinel
-
NoteResearch use only, not for human use.
-
Brief DescriptionLicostinel is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
-
DescriptionLicostinel is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
-
In Vitro——
-
In VivoAnimal Model:The permanent model of middle cerebral artery occlusion in fisher 344 rats and CD-1 mice. The transient model of focal ischemia in Wistar and Sprague –Dawley rats.Dosage:5 mg/kg bolus 3.5 mg/kg/h for 6h, 10 mg/kg bolus 7.0 mg/kg/h for 6h Administration:A single intravenous injection bolus continuous infusionResult:Decreased infarct size.Animal Model:Male Sprague-Dawley rats Dosage:20, 40, 80 mg/kg for intraperitoneal injection (i.p.) bolus 7 mg/kg/h , 30mins Administration:Intravenous injection (i.v.) bolus continuous infusionResult:Reduced the rate of spreading depression and EEG activity in the rat brain in a dose-dependent manner.
-
SynonymsACEA-1021 | ACEA 1021 | ACEA1021 | CGP-63446 | CGP 63446
-
PathwayNeuroscience
-
TargetGluR
-
RecptorNucleoside
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number153504-81-5
-
Formula Weight276.03
-
Molecular FormulaC8H3Cl2N3O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 12.5 mg/mL (45.28 mM)
-
SMILES[O-][N+](=O)c1c(Cl)c(Cl)cc2[nH]c(=O)c(=O)[nH]c12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Taniguchi T, et al. Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis. Nat Chem Biol. 2018 Nov;14(11):1010-1020.
molnova catalog
related products
-
XAP044
XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm.
-
(-)-Camphoric acid
(-)-Camphoric acid is a less active enantiomer of Camphoric acid which induces GluR expression.
-
Philanthotoxin 74 di...
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
