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TC LPA5 4

CAS No. 1393814-38-4

TC LPA5 4( —— )

Catalog No. M33938 CAS No. 1393814-38-4

TC LPA5 4 is a LPA5 receptor antagonist.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	109	In Stock
5MG	100	In Stock
10MG	160	In Stock
25MG	341	In Stock
50MG	500	In Stock
100MG	737	In Stock
200MG	1014	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

TC LPA5 4
Note

Research use only, not for human use.
Brief Description

TC LPA5 4 is a LPA5 receptor antagonist.
Description

TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells.
In Vitro

——
In Vivo

Animal Model:BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts) Dosage:10 mg/kg Administration:Intraperitoneal injection; 5 days/week for 2 weeks Result:Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.
Synonyms

——
Pathway

GPCR/G Protein
Target

LPA Receptor
Recptor

LPA Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1393814-38-4
Formula Weight

410.89
Molecular Formula

C23H23ClN2O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (152.11 mM; Ultrasonic )
SMILES

C(O)(=O)C=1C=C(N(N1)C2=CC(OC)=CC=C2)C3=CC(Cl)=C(C=C3)C4CCCCC4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kozian DH, et al. Selective non-lipid modulator of LPA5 activity in human platelets. Bioorg Med Chem Lett. 2012;22(16):5239-5243.?

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