HG-14-10-04( HG-14-10-04 )

Catalog No. M17255 CAS No. 1356962-34-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

HG-14-10-04
Note

Research use only, not for human use.
Brief Description

HG-14-10-04 is a potent and specific ALK inhibitor.
Description

HG-14-10-04 is a novel potent and specific ALK inhibitor.
In Vitro

HG-14-10-04 (example 10) has inhibitory activity against ALK kinase with an IC50 of 20 nM.HG-14-10-04 (compound 17b) exhibits kinase inhibitory activity against EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS with IC50s of 15.6 nM, 22.6 nM and 124.5 nM, respectively.
In Vivo

——
Synonyms

HG-14-10-04
Pathway

GPCR/G Protein
Target

LPA Receptor
Recptor

ALK
Research Area

Cancer
Indication

——

CAS Number

1356962-34-9
Formula Weight

532.08
Molecular Formula

C29H34ClN7O
Purity

>98% (HPLC)
Solubility

DMSO : 13.3 mg/mL. 25.00 mM;
SMILES

CN1CCN(C2CCN(c3ccc(Nc4ncc(Cl)c(c5c[nH]c6c5cccc6)n4)c(OC)c3)CC2)CC1
Chemical Name

[5-Chloro-4-(1H-indol-3-yl)-pyrimidin-2-yl]-{2-methoxy-4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-amine

1.U.S. Pat. Appl. Publ. (2012), US 20120028924 A1

Calculator

molnova catalog