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PB28 dihydrochloride
CAS No. 172907-03-8
PB28 dihydrochloride( —— )
Catalog No. M33903 CAS No. 172907-03-8
σ2 receptor agonist
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 379 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePB28 dihydrochloride
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NoteResearch use only, not for human use.
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Brief Descriptionσ2 receptor agonist
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DescriptionPB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with a Ki of 0.38 nM. PB28 dihydrochloride is less affinity for other receptors. PB28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride can modulate SARS-CoV-2-human protein-protein interaction. PB28 dihydrochloride induces caspase-independent apoptosis and has antitumor activity.
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In VitroCell Viability Assay Cell Line:MCF7 and MCF7 ADR cells Concentration:25 nM and 15 nM Incubation Time:24 hours, 48 hours Result:Showed an accumulation in the G0-G1 phase for MCF7 and MCF7 ADR cells that were time and concentration independent.
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In VivoAnimal Model:C57BL/6 female mice (10 weeks old) injected with Panc02 cells Dosage:10.7 mg/mL Administration:Intraperitoneal injection; daily; for two weeks Result:Inhibited tumor growth in Panc02 tumor burden mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number172907-03-8
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Formula Weight443.49
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Molecular FormulaC24H40Cl2N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:? H2O : 9 mg/mL (20.29 mM)DMSO : 5 mg/mL (11.27 mM; Ultrasonic (<60°C); )
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SMILESCOC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Amalia Azzariti, et al. Cyclohexylpiperazine Derivative PB28, a sigma2 Agonist and sigma1 Antagonist Receptor, Inhibits Cell Growth, Modulates P-glycoprotein, and Synergizes With Anthracyclines in Breast Cancer. Mol Cancer Ther. 2006 Jul;5(7):1807-16.?
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