Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation.

FG 7142?also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM).?FG 7142?can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex.?FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).?

Fosaprepitant Benzyl Ester