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ML 10302 hydrochloride

CAS No. 186826-17-5

ML 10302 hydrochloride( —— )

Catalog No. M33888 CAS No. 186826-17-5

ML 10302 hydrochloride is a specific agonist 5-HT4 and binds 5-HT receptors with Kis of 1.07 nM and 782 nM for 5-HT4 and 5-HT3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML 10302 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    ML 10302 hydrochloride is a specific agonist 5-HT4 and binds 5-HT receptors with Kis of 1.07 nM and 782 nM for 5-HT4 and 5-HT3.
  • Description
    ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.
  • In Vitro
    ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay.
  • In Vivo
    ML 10302 hydrochloride (20?mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice.Animal Model:8-weeks old adult male C57BL/6j wild-type mice (23-27?g)Dosage:5 mg/kg, 10 mg/kg, 20?mg/kg Administration:Subcutaneous injection Result:Significantly increased sAPPα level in the cortex.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    186826-17-5
  • Formula Weight
    349.25
  • Molecular Formula
    C15H22Cl2N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COC1=CC(=C(C=C1C(=O)OCCN2CCCCC2)Cl)N.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.
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