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ML 10302 hydrochloride
CAS No. 186826-17-5
ML 10302 hydrochloride( —— )
Catalog No. M33888 CAS No. 186826-17-5
ML 10302 hydrochloride is a specific agonist 5-HT4 and binds 5-HT receptors with Kis of 1.07 nM and 782 nM for 5-HT4 and 5-HT3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | Get Quote |
|
| 10MG | 67 | Get Quote |
|
| 25MG | 141 | Get Quote |
|
| 50MG | 262 | Get Quote |
|
| 100MG | 315 | Get Quote |
|
| 200MG | 441 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameML 10302 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionML 10302 hydrochloride is a specific agonist 5-HT4 and binds 5-HT receptors with Kis of 1.07 nM and 782 nM for 5-HT4 and 5-HT3.
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DescriptionML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.
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In VitroML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay.
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In VivoML 10302 hydrochloride (20?mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice.Animal Model:8-weeks old adult male C57BL/6j wild-type mice (23-27?g)Dosage:5 mg/kg, 10 mg/kg, 20?mg/kg Administration:Subcutaneous injection Result:Significantly increased sAPPα level in the cortex.
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Synonyms——
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number186826-17-5
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Formula Weight349.25
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Molecular FormulaC15H22Cl2N2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=CC(=C(C=C1C(=O)OCCN2CCCCC2)Cl)N.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.
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