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Cyclapolin 9

CAS No. 40533-25-3

Cyclapolin 9( —— )

Catalog No. M33843 CAS No. 40533-25-3

Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 240 In Stock
5MG 217 In Stock
10MG 337 In Stock
25MG 541 In Stock
50MG 731 In Stock
100MG 995 In Stock
200MG Get Quote In Stock
500MG 2000 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Cyclapolin 9
  • Note
    Research use only, not for human use.
  • Brief Description
    Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.
  • Description
    Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases.
  • In Vitro
    Cyclapolin 9 (3 μM) reduces electric field stimulation (EFS)-induced contractions of prostate strips. The α1-adrenergic smooth muscle contraction in the human prostate can be inhibited by Cyclapolin 9.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PLK
  • Recptor
    PLK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    40533-25-3
  • Formula Weight
    307.21
  • Molecular Formula
    C9H4F3N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20 mg/mL (65.10 mM; Ultrasonic (<80°C)
  • SMILES
    NC(=O)c1sc2c(cc(cc2[n+]1[O-])C(F)(F)F)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734.?
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