Ilexsaponin A1( —— )

Catalog No. M17803 CAS No. 108524-93-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Ilexsaponin A1
Note

Research use only, not for human use.
Brief Description

Ilexsaponin A shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.
Description

Ilexsaponin A shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.
In Vitro

Ilexsaponin Asignificantly reduces proapoptotic proteins including caspase-3, cleaved caspase-3 and bax and increases anti-apoptotic protein bcl-2 in hypoxia/reoxygenation cardiomyocytes. Ilexsaponin A treatment increases the expression levels of p-Akt in hypoxia/reoxygenation cellular model and myocardial ischemia/reperfusion animal model.
In Vivo

Ilexsaponin A (10 or 40 mg/kg) reduce the myocardial infarct size in a dose dependent manner in male Sprague-Dawley rats weighing 280-320 g.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

PLK
Recptor

Others
Research Area

——
Indication

——

CAS Number

108524-93-2
Formula Weight

664.83
Molecular Formula

C36H56O11
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (150.42 mM)
SMILES

[H][C@@]1([C@]2(CCC([C@]3(C(O)=O)C)[C@@]1(CC[C@@H]3O)C)C)CC=C4[C@@]5([C@](O)([C@@H](CC[C@]5(C(O[C@@H]([C@@H]6O)O[C@@H]([C@H]([C@@H]6O)O)CO)=O)CC[C@]42C)C)C)[H]
Chemical Name

——