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CFM 4

CAS No. 331458-02-7

CFM 4( —— )

Catalog No. M33838 CAS No. 331458-02-7

CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 55 Get Quote
5MG 76 Get Quote
10MG 122 Get Quote
25MG 242 Get Quote
50MG 362 Get Quote
100MG 518 Get Quote
500MG 1098 Get Quote
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Biological Information

  • Product Name
    CFM 4
  • Note
    Research use only, not for human use.
  • Brief Description
    CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.
  • Description
    CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    APC | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    331458-02-7
  • Formula Weight
    405.9
  • Molecular Formula
    C22H16ClN3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (61.59 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1C2(C=3C(N1CC4=C(Cl)C=CC=C4)=CC=CC3)SC(=NN2)C5=CC=CC=C5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017.?
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