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S-Methylisothiourea sulfate
CAS No. 867-44-7
S-Methylisothiourea sulfate( —— )
Catalog No. M33814 CAS No. 867-44-7
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 31 | In Stock |
|
| 100MG | 45 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 110 | In Stock |
|
| 1G | 163 | In Stock |
|
Biological Information
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Product NameS-Methylisothiourea sulfate
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NoteResearch use only, not for human use.
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Brief DescriptionS-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock.
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DescriptionS-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock.
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In Vitro——
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In VivoAnimal Model:Male Wistar rats (260-320 g)Dosage:0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg Administration:Intravenous injection Result:Caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats; Inhibited iNOS activity measured in homogenates of lung.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetNOS
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RecptorNOS | HSV | NO Synthase
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Research Area——
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Indication——
Chemical Information
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CAS Number867-44-7
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Formula Weight139.18
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Molecular FormulaC2H6N2S·1/2H2O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 65 mg/mL (467.02 mM; Ultrasonic)DMSO : < 1 mg/mL (insoluble or slightly soluble)
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SMILESCSC(N)=N.CSC(N)=N.OS(O)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. C Szabó, et al. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26): 12472-12476.?
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