Cart
sales@molnova.com
Home - Products - Angiogenesis - VEGFR - AMG-Tie2-1

AMG-Tie2-1

CAS No. 870223-96-4

AMG-Tie2-1( —— )

Catalog No. M33796 CAS No. 870223-96-4

AMG-Tie2-1 is a potent inhibitor of endothelial endothelial cell kinase 2 (Tie2) and VEGFR2 with anticancer and antitumor activity that affects cardiovascular production, and may be used in the study of cardiovascular disease and cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 154 In Stock
10MG 226 In Stock
25MG 372 In Stock
50MG 621 In Stock
100MG 1014 In Stock
200MG 1516 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AMG-Tie2-1
  • Note
    Research use only, not for human use.
  • Brief Description
    AMG-Tie2-1 is a potent inhibitor of endothelial endothelial cell kinase 2 (Tie2) and VEGFR2 with anticancer and antitumor activity that affects cardiovascular production, and may be used in the study of cardiovascular disease and cancer.
  • Description
    AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM.
  • In Vitro
    AMG-Tie2-1 (compound 15) inhibits Tie-2 phosphorylation in EA.hy926 human endothelial cells (IC50=10 nM).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    VEGFR
  • Recptor
    VEGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    870223-96-4
  • Formula Weight
    479.45
  • Molecular Formula
    C25H20F3N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=CC=CC(=C1)C(F)(F)F)C2=CC=C(C(OC=3N=CC=CC3C4=NC(=NC=C4)NC)=C2)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brian L Hodous, et al. Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J Med Chem. 2007 Feb 22;50(4):611-26.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Veratric acid

    Veratric acid plays an important role in producing antibiotics and various dyes.

  • Ellipticine

    Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action.

  • TG 100801

    TG 100801 is a dual inhibitor of VEGFr2 and Src family (Src and YES) kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).

Sign In Join Free