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AS 1892802
CAS No. 928320-12-1
AS 1892802( —— )
Catalog No. M33782 CAS No. 928320-12-1
AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 117 | In Stock |
|
| 5MG | 93 | In Stock |
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| 10MG | 169 | In Stock |
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| 25MG | 377 | In Stock |
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| 50MG | 548 | In Stock |
|
| 100MG | 784 | In Stock |
|
| 200MG | 1079 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAS 1892802
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NoteResearch use only, not for human use.
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Brief DescriptionAS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively.
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DescriptionAS1892802 is a potent, orally active, and highly selective inhibitor of ROCK. The onset of antinociceptive effect of AS1892802 is as fast as those of Tramadol and Diclofenac. AS1892802 did not induce gastric irritation or abnormal behavior. AS1892802 is an attractive analgesic profile for the research of severe osteoarthritis pain.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetROCK
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RecptorROCK
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Research Area——
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Indication——
Chemical Information
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CAS Number928320-12-1
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Formula Weight333.38
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Molecular FormulaC20H19N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (374.95 mM; Ultrasonic (<60°C)
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SMILESN(C(N[C@H](CO)C1=CC=CC=C1)=O)C2=CC=C(C=C2)C=3C=CN=CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yoshimi E, et al. Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J Pharmacol Exp Ther. 2010;334(3):955-963.?
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