Resistomycin

Research use only, not for human use.

Resistomycin (Geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis.

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis.

Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation.Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance. Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells.Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo.

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Microbiology/Virology

Antibiotic

Antibiotic

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20004-62-0

376.36

C22H16O6

>98% (HPLC)

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Cc1cc(O)c2C(=O)c3c(O)cc(O)c4C(=O)C(C)(C)c5cc(O)c1c2c5-c34

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(-20℃)

With Ice Pack

≥ 2 years