Arbutamine( —— )

Catalog No. M32786 CAS No. 128470-16-6

Arbutamine (GP 21213) is a novel potent non-selective beta-adrenoceptor agonist with alpha-1-sympathomimetic activity.Arbutamine promotes cardiac stress and increases heart rate, cardiac contractility.

Purity : >98% (HPLC)

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Biological Information

Product Name

Arbutamine
Note

Research use only, not for human use.
Brief Description

Arbutamine (GP 21213) is a novel potent non-selective beta-adrenoceptor agonist with alpha-1-sympathomimetic activity.Arbutamine promotes cardiac stress and increases heart rate, cardiac contractility.
Description

Arbutamine is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine stimulates cardiac β1-, tracheal β2-, and adiopocyte β3- adrenergic receptors. Arbutamine provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine can be used for cardiac stress agent .
In Vitro

Arbutamine (0.1-100 nM) increases heart contractile force and pD2 value of 8.45. Arbutamine has the affinity constants (KA) value of 7.32 for cardiac β1-adrenergic receptors.
In Vivo

Arbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg).
Synonyms

——
Pathway

GPCR/G Protein
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

128470-16-6
Formula Weight

317.38
Molecular Formula

C18H23NO4
Purity

>98% (HPLC)
Solubility

——
SMILES

O[C@@H](CNCCCCc1ccc(O)cc1)c1ccc(O)c(O)c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ruiz M, et al. Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m)Tc-sestamibi versus (201)Tl. J Nucl Med. 2002 May;43(5):664-70.?

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