Pyronine B

CAS No. 2150-48-3

Pyronine B( —— )

Catalog No. M33642 CAS No. 2150-48-3

Pyronine B (NSC 44690) is a fluorophore with low relative fluorophore brightness and a small hydrophobic (SH) protein channel inhibitor, which is used for staining of bacteria and mycobacteria and in the spectrophotometric determination of ultra-trace ruthenium.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Pyronine B
  • Note
    Research use only, not for human use.
  • Brief Description
    Pyronine B (NSC 44690) is a fluorophore with low relative fluorophore brightness and a small hydrophobic (SH) protein channel inhibitor, which is used for staining of bacteria and mycobacteria and in the spectrophotometric determination of ultra-trace ruthenium.
  • Description
    Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor.
  • In Vitro
    Pyronin B (0-15 μM) inhibits channel activity of approximately 60% of small hydrophobic (SH) proteins at a concentration of 10 μM, and the Kd value of 6.8 μM.Pyronin B (0-0.25 μM) affects RSV replication in Vero cells in a dose-dependent manner, and its TCID50 (50% tissue culture infection dose) = 0 at the concentration of 0.25 μM.Pyronin B (10 μM) can react with bromate in an oxidation reaction and the reaction rate increases dramatically with the addition of trace amounts of Ti (IV) with the characteristic absorption spectra of 555 nm.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2150-48-3
  • Formula Weight
    358.91
  • Molecular Formula
    C21H27ClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20.83 mg/mL (58.04 mM; Ultrasonic (<60°C)
  • SMILES
    [Cl-].[O+]=1C=2C=C(C=CC2C=C3C=CC(=CC13)N(CC)CC)N(CC)CC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yan Li, et al. Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment. J Virol. 2014 Oct;88(20):11899-914.?
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