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TC-I 2014
CAS No. 1221349-53-6
TC-I 2014( —— )
Catalog No. M33511 CAS No. 1221349-53-6
TC-I 2014 shows antiallodynic properties in pain models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 176 | In Stock |
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| 5MG | 273 | In Stock |
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| 10MG | 407 | In Stock |
|
| 25MG | 631 | In Stock |
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| 50MG | 891 | In Stock |
|
| 100MG | 1152 | In Stock |
|
| 500MG | 2358 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTC-I 2014
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NoteResearch use only, not for human use.
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Brief DescriptionTC-I 2014 shows antiallodynic properties in pain models.
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DescriptionTC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models.
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In VitroTC-I 2014 (compound 5) potently inhibits cold-induced TRPM8 currents in HEK293 cells stably expressing canine or human TRPM8, with IC50 values of 0.413 and 1 nM, respectively.
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In VivoTC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS.Animal Model:TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS.Dosage:3, 5.6, 10 mg/kg.Administration:Orally once.Result:Produced greater than 90% inhibition at 3, 5.6, and 10 mg/kg administered 2 h prior to icilin challenge.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRP/TRPV Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1221349-53-6
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Formula Weight467.41
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Molecular FormulaC23H19F6N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (534.86 mM; Ultrasonic )
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SMILESFC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54(1):233-47.?
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