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SIB-1553A hydrochloride

CAS No. 191611-89-9

SIB-1553A hydrochloride( —— )

Catalog No. M33497 CAS No. 191611-89-9

SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SIB-1553A hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.
  • Description
    SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders.
  • In Vitro
    SIB-1553A displaces the binding of [H]nicotine (NIC) to the rat brain nAChRs with an IC50 value of 110 nM.In calcium flux assays, SIB-1553A (0.1-5 μM), shows a greater selectivity for beta4-subunit containing recombinant hnAChRs (alpha2beta4, alpha3beta4 and alpha4beta4) vs. beta2-subunit containing nAChRs (alpha4beta2 and alpha3beta2) both in terms of efficacy and potency.
  • In Vivo
    SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels.Animal Model:Male Sprague-Dawley rats (200-250 g)Dosage:1, 2, 4, 10, 20 and 40 mg/kg Administration:s.c.Result:Induced hippocampal ACh release.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    AChR
  • Recptor
    AChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    191611-89-9
  • Formula Weight
    273.82
  • Molecular Formula
    C13H20ClNOS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:? H2O : ≥ 27.38 mg/mL (99.99 mM)
  • SMILES
    Cl.CN1CCCC1CCSc1ccc(O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Vernier JM, et al. 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem. 1999 May 20;42(10):1684-6.?
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