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SIB-1553A hydrochloride
CAS No. 191611-89-9
SIB-1553A hydrochloride( —— )
Catalog No. M33497 CAS No. 191611-89-9
SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 79 | In Stock |
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| 5MG | 134 | In Stock |
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| 10MG | 216 | In Stock |
|
| 25MG | 357 | In Stock |
|
| 50MG | 493 | In Stock |
|
| 100MG | 663 | In Stock |
|
| 200MG | 895 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSIB-1553A hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionSIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.
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DescriptionSIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders.
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In VitroSIB-1553A displaces the binding of [H]nicotine (NIC) to the rat brain nAChRs with an IC50 value of 110 nM.In calcium flux assays, SIB-1553A (0.1-5 μM), shows a greater selectivity for beta4-subunit containing recombinant hnAChRs (alpha2beta4, alpha3beta4 and alpha4beta4) vs. beta2-subunit containing nAChRs (alpha4beta2 and alpha3beta2) both in terms of efficacy and potency.
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In VivoSIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels.Animal Model:Male Sprague-Dawley rats (200-250 g)Dosage:1, 2, 4, 10, 20 and 40 mg/kg Administration:s.c.Result:Induced hippocampal ACh release.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number191611-89-9
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Formula Weight273.82
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Molecular FormulaC13H20ClNOS
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Purity>98% (HPLC)
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SolubilityIn Vitro:? H2O : ≥ 27.38 mg/mL (99.99 mM)
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SMILESCl.CN1CCCC1CCSc1ccc(O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vernier JM, et al. 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem. 1999 May 20;42(10):1684-6.?
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