Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - AChR - VU0453595

VU0453595

CAS No. 1432436-13-9

VU0453595( VU-0453595 | VU 0453595 )

Catalog No. M27939 CAS No. 1432436-13-9

VU0453595 is a M1 positive allosteric modulator (PAM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 57 Get Quote
5MG 87 Get Quote
10MG 147 Get Quote
25MG 286 Get Quote
50MG 444 Get Quote
100MG 647 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    VU0453595
  • Note
    Research use only, not for human use.
  • Brief Description
    VU0453595 is a M1 positive allosteric modulator (PAM).
  • Description
    VU0453595 is a M1 positive allosteric modulator (PAM).
  • In Vitro
    Application of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs).
  • In Vivo
    VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD).VU0453595 (1-10?mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration. Animal Model:Male C57BL6/J mice (8-9 weeks old)Dosage:1, 3, or 10?mg/kg Administration:Intraperitoneal (i.p.); 10?mL/kg; administered 30?min before the social interaction test Result:Rescued deficits in social interaction observed in PCP-treated mice.
  • Synonyms
    VU-0453595 | VU 0453595
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    AChR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1432436-13-9
  • Formula Weight
    322.343
  • Molecular Formula
    C18H15FN4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (310.23 mM)
  • SMILES
    Cn1cc(cn1)-c1ccc(CN2Cc3ncccc3C2=O)c(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Scott DE, et al. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. ChemMedChem. 2015 Feb;10(2):296-303.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Anisodamine B

    Anisodamine (6-beta-Hydroxyhyoscyamine) is an antagonist of muscarinic and nicotinic cholinoceptor with similar affinities at the muscarinic receptor as scopolamine and atropine.

  • Pipecuronium bromide

    Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics.

  • Lobelanidine

    Lobelanidine (8,10-Diphenyllobelidiol), which can be extracted from the above-ground parts of Lobelia chinensis Lour and Lobelia tupa, is an analogue of lobeline and shows a moderate affinity for nAChR.

Sign In Join Free