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SDZ281-977
CAS No. 150779-71-8
SDZ281-977( —— )
Catalog No. M33494 CAS No. 150779-71-8
SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 258 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 376 | In Stock |
|
| 25MG | 753 | In Stock |
|
| 50MG | 1144 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSDZ281-977
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NoteResearch use only, not for human use.
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Brief DescriptionSDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.
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DescriptionSDZ 281-977 is a derivative of the EGF receptor tyrosine kinase inhibitor Lavendustin A.
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In VitroThe anticancer profile of SDZ 281-977 is investigated in nude mice bearing the human tumor cell lines A431 (vulvar carcinoma cells), MIA PaCa-2 (pancreatic tumor cells) and MDA-MB-231 (breast carcinoma cells). These cell lines are selected because of their sensitivity for SDZ 281-977. The IC50 values for inhibition of growth of A431, MIA PaCa-2 and MDA-MB-231 cells are 0.21 μM, 0.29 μM and 0.43 μM, respectively.
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In VivoNude mice bearing A431 human vulvar carcinomas receive intravenous injections of SDZ 281-977 (1-10 mg/kg) for 4 weeks. This treatment results in a dose-dependent inhibition of tumor growth. Orally administered SDZ 281-977 (30 mg/kg) induces a 54% inhibition of A431 tumor growth after 3 weeks of treatment. The above regimens are well tolerated. No significant change in body weight occurred during treatment.
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number150779-71-8
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Formula Weight316.35
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Molecular FormulaC18H20O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (316.11 mM; Ultrasonic )
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SMILESCOC(=O)c1cc(CCc2cc(OC)ccc2OC)ccc1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cammisuli S, et al. SDZ 281-977: a modified partial structure of lavendustin A that exerts potent and selective antiproliferative activities in vitro and in vivo. Int J Cancer. 1996 Jan 26;65(3):351-9.?
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