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PF-06446846 hydrochloride
CAS No. 1632250-50-0
PF-06446846 hydrochloride( —— )
Catalog No. M33462 CAS No. 1632250-50-0
PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 117 | In Stock |
|
| 10MG | 198 | In Stock |
|
| 25MG | 471 | In Stock |
|
| 50MG | 693 | In Stock |
|
| 100MG | 1014 | In Stock |
|
| 200MG | 1376 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-06446846 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression.
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DescriptionPF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochlorideinhibits PCSK9 by inducing the ribosome to stall around codon 34.
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In VitroPF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM.
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In VivoPF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.Animal Model:Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)Dosage:5, 15, and 50 mg/kg Administration:Oral gavage; daily for 14 daysResult:Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1632250-50-0
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Formula Weight
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Molecular FormulaC22H20CIN7O.XHCl
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (531.52 mM; Ultrasonic ) H2O : 100 mg/mL (212.61 mM; Ultrasonic)
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SMILESCl.Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15(3):e2001882.?
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