Oxyphenbutazone
CAS No. 129-20-4
Oxyphenbutazone( —— )
Catalog No. M33449 CAS No. 129-20-4
Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 74 | In Stock |
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| 2MG | 43 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 103 | In Stock |
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| 25MG | 174 | In Stock |
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| 50MG | 256 | In Stock |
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| 100MG | 384 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameOxyphenbutazone
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NoteResearch use only, not for human use.
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Brief DescriptionOxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative.
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DescriptionOxyphenbutazone is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
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In VitroOxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells.Oxyphenbutazone (2.5-7.5 μM; 48 hours) co-treatment with (MTX, 0.25-1.0 μM) shows potential cytotoxicity against Hep3B cells.Oxyphenbutazone exhibits reparative effects in the hepatocytes.Cell Cytotoxicity Assay Cell Line:Hep3B cells Concentration:2.5 μM, 5 μM, 7.5 μM Incubation Time:48 hours Result:Enhanced the cytotoxicity of MTX.
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In VivoOxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).Animal Model:Wistar strain albino male rats (5-6 weeks; 150-220 g) Dosage:70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week) Administration:PO; once a week; in two divided doses; for 13 weeks Result:Exerted potential anticancer activity in rats when co-treatment with MTX.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research Area——
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Indication——
Chemical Information
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CAS Number129-20-4
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Formula Weight324.37
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Molecular FormulaC19H20N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (308.29 mM; Ultrasonic )
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SMILESCCCCC1C(=O)N(N(C1=O)c1ccc(O)cc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444(1-2):187-196.?
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