Cart
sales@molnova.com
MK-3328
CAS No. 1201323-97-8
MK-3328( —— )
Catalog No. M33432 CAS No. 1201323-97-8
MK-3328 has a high affinity for β-Amyloid (IC50:10.5 nM), and can be used as a candidate PET ligand for clinical assessment of β-amyloid plaque load. MK-3328 is a potential treatment for Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 787 | In Stock |
|
| 10MG | 1074 | In Stock |
|
| 25MG | 1511 | In Stock |
|
| 50MG | 1841 | In Stock |
|
| 100MG | 2325 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 4557 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMK-3328
-
NoteResearch use only, not for human use.
-
Brief DescriptionMK-3328 has a high affinity for β-Amyloid (IC50:10.5 nM), and can be used as a candidate PET ligand for clinical assessment of β-amyloid plaque load. MK-3328 is a potential treatment for Alzheimer's disease.
-
DescriptionMK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC50 of 10.5 nM.
-
In VitroMK-3328 exhibits amyloid binding potency balanced with low levels of nonspecific binding.
-
In VivoIn vivo, [18F]MK-3328 demonstrates favorable kinetics, exhibiting high brain uptake and good washout in normal rhesus monkey positron emission tomography (PET) imaging studies.
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetBeta Amyloid
-
RecptorBeta Amyloid
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1201323-97-8
-
Formula Weight268.25
-
Molecular FormulaC14H9FN4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESFC=1N=C2OC(=NC2=CC1)C=3C=C4C(=NC3)N(C)C=C4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Harrison ST, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Apr 18;2(7):498-502.?
molnova catalog
related products
-
Sophoridine
Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead.
-
β-amyloid 1-11
Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid of Alzheimer’s disease patients.
-
Otophylloside B
Qingyangshengenin B is a C-21 steroidal glycoside isolated from Qingyangshen.?
