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DRF-1042
CAS No. 200619-13-2
DRF-1042( —— )
Catalog No. M33344 CAS No. 200619-13-2
DRF-1042, an orally active camptothecin analog, exhibits anticancer and insecticidal activities by inhibiting DNA topoisomerase I. It has been studied for its efficacy against solid tumors, including prostate and colon cancers.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 101 | In Stock |
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| 25MG | 207 | In Stock |
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| 50MG | 324 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDRF-1042
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NoteResearch use only, not for human use.
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Brief DescriptionDRF-1042, an orally active camptothecin analog, exhibits anticancer and insecticidal activities by inhibiting DNA topoisomerase I. It has been studied for its efficacy against solid tumors, including prostate and colon cancers.
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DescriptionDRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype.
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In VitroDRF-1042 demonstrates superior lactone stability and good in vitro anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype.
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In VivoIn clonogenic assay against murine, canine and human bone marrow cells, DRF-1042 treatment shows less mylosupression that supports the possibility of protracted dose schedule in both experimental and clinical studies.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetTopoisomerase
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RecptorTopoisomerase
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Research Area——
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Indication——
Chemical Information
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CAS Number200619-13-2
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Formula Weight408.4
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Molecular FormulaC22H20N2O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (122.43 mM; Ultrasonic )
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SMILESCC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3C(OCCO)n1c2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chatterjee A, et al. Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novelcamptothecin analog, in refractory cancer patients in a bridging phase I study. J Clin Pharmacol. 2005 Apr;45(4):453-60.?
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