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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - JWG-071

JWG-071

CAS No. 2250323-50-1

JWG-071( —— )

Catalog No. M33288 CAS No. 2250323-50-1

JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JWG-071
  • Note
    Research use only, not for human use.
  • Brief Description
    JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.
  • Description
    JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology.
  • In Vitro
    JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    Epigenetic Reader Domain | ERK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2250323-50-1
  • Formula Weight
    612.77
  • Molecular Formula
    C34H44N8O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (163.20 mM; Ultrasonic )
  • SMILES
    CCC(C)N1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3OC)C(=O)N3CCC(CC3)N3CCN(C)CC3)nc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448?
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