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Barbadin
CAS No. 356568-70-2
Barbadin( —— )
Catalog No. M33283 CAS No. 356568-70-2
Barbadin is a novel and specific inhibitor of β-arrestin/β2-adaptin interaction with an IC50 value of 19.1 μM for β-arestin1 and 15.6 μM for β-arestin2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 135 | In Stock |
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| 5MG | 123 | In Stock |
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| 10MG | 183 | In Stock |
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| 25MG | 310 | In Stock |
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| 50MG | 451 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBarbadin
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NoteResearch use only, not for human use.
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Brief DescriptionBarbadin is a novel and specific inhibitor of β-arrestin/β2-adaptin interaction with an IC50 value of 19.1 μM for β-arestin1 and 15.6 μM for β-arestin2.
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DescriptionBarbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis.
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In VitroBarbadin (4 h) treatment reduces cell viability and induces apoptosis.?Barbadin (2 h) treatment arrests breast cancer cells in G0/G1 phase.Apoptosis Analysis Cell Line:MDA MB-231 cells Concentration:Incubation Time:4 hoursResult:Exhibited morphological characteristics of apoptosis including shrinkage, rounding and detachment, the percent of cell viability was reduced to 69.1% and apoptosis was developed in 29.9% of cells starved with EBSS (Earle’s balanced salt solution).Cell Cycle AnalysisCell Line:MDA MB-231 cells Concentration:Incubation Time:2 hours Result:Arrested 63.7% of cells in G0/G1 phase.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorArrestin
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Research Area——
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Indication——
Chemical Information
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CAS Number356568-70-2
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Formula Weight333.41
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Molecular FormulaC19H15N3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (149.97 mM; Ultrasonic )
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SMILESNn1cnc2scc(-c3ccc(Cc4ccccc4)cc3)c2c1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beautrait A, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.?
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