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β-Glucuronidase-IN-1
CAS No. 484006-66-8
β-Glucuronidase-IN-1( —— )
Catalog No. M33191 CAS No. 484006-66-8
β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 221 | In Stock |
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| 50MG | 323 | In Stock |
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| 100MG | 480 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 1014 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Nameβ-Glucuronidase-IN-1
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NoteResearch use only, not for human use.
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Brief Descriptionβ-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase.
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Descriptionβ-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibitingan IC50 and a Ki of 283 nM and 164 nM, respectively.
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In Vitroβ-Glucuronidase-IN-1 (Inhibitor 1) (0.01-100 μM) inhibits E. coli?β-glucuronidase activity as a dose-dependent manner and exhibits an IC50 and a Ki value with 283 nM and 164 nM, respectively.β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells (EC50=17.7 nM), it does not affect bacterial cell growth under aerobic or anaerobic conditions or killing mammalian epithelial cells. Cell Viability AssayCell Line:CMT93, CaCO-2, HCT116 cells Concentration:100 μM Incubation Time:24hours, 48 hours and 72 hours Result:Did not impact mammalian cell survival and any reduction in cell viability were attributed to the presence of DMSO.
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In Vivoβ-Glucuronidase-IN-1 (oral gavage; 10 μg; twice per day; 11 days) protects the mouse GI epithelium from CPT-11–induced damage and protects the glandular structure of CPT-11-treated intestinal tissues.Animal Model:Healthy 6- to 8-week-old Balb/cJ mice Dosage:10 μg Administration:Oral gavage; twice per day; 11 daysResult:Alleviated CPT-11-induced toxicity in mice.
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Synonyms——
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number484006-66-8
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Formula Weight425.54
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Molecular FormulaC23H27N3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (235.00 mM; Ultrasonic (<60°C)
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SMILESCCOc1ccc(NC(=S)N(CCO)Cc2cc3cc(C)cc(C)c3[nH]c2=O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wallace BD, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.Science.?2010 Nov 5;330(6005):831-5.?
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