Tin-protoporphyrin IX dichloride

Research use only, not for human use.

Tin-protoporphyrin IX dichloride (SnPPIX dichloride) is an HO-1) inhibitor with antiviral activity that inhibits dengue and yellow fever viruses.

Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.

Tin protoporphyrin IX dichloride (20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, Tin protoporphyrin IX dichloride has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.Cell Viability Assay Cell Line:Capan-1, CD18/HPAF, PDAC cells Concentration:20 μM, 50 μM Incubation Time:24 or 72 hours Result:Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.

Tin protoporphyrin IX dichloride (intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.Animal Model:Male and female athymic nude mice with PDAC cell-derived xenograft tumorsDosage:5 mg/kg Administration: Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20 Result:Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).

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Autophagy

Autophagy

Autophagy | Virus Protease

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14325-05-4

750.26

C34H32Cl2N4O4Sn

>98% (HPLC)

In Vitro:?0.1 M NaOH : 14.29 mg/mL (19.05 mM; Ultrasonic; (NaOH，pH≈11))1M NaOH : 5 mg/mL (6.66 mM; Ultrasonic)DMF : 1 mg/mL (1.33 mM) DMSO : 0.5 mg/mL (0.67 mM)

O=C(CCC1=C(C)C2=CC3=C(C)C(C=C)=C4C=C5C(C)=C(C=C)C6=[N]5[Sn+4]([Cl-])([Cl-])([N-]43)([N-]78)[N]2=C1C=C8C(CCC([O-])=O)=C(C)C7=C6)[O-].[H+].[H+]

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(-20℃)

With Ice Pack

≥ 2 years