AUTEN-99 hydrobromide( AUTEN99 hydrobromide )

Catalog No. M10241 CAS No. 1049780-58-6

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HNMR

HPLC

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Product Name

AUTEN-99 hydrobromide
Note

Research use only, not for human use.
Brief Description

A small molecule autophagy enhancer that inhibit the myotubularin-related phosphatase MTMR14/Jumpy.
Description

A small molecule autophagy enhancer that inhibit the myotubularin-related phosphatase MTMR14/Jumpy; induces autophagic flux and promotes cell survival in mammalian cell cultures; increases the number of autophagic structures in mice and Drosophila, and effectively penetrates through a blood-brain barrier model; impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson's and Huntington's diseases.
In Vitro

——
In Vivo

——
Synonyms

AUTEN99 hydrobromide
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

Neurological Disease
Indication

——

CAS Number

1049780-58-6
Formula Weight

359.285
Molecular Formula

C17H15BrN2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 7.5 mg/mL (20.88 mM)
SMILES

C1CN2C=C(SC2=N1)C3=CC=C(C=C3)C4=CC=CC=C4.Br
Chemical Name

2-([1,1'-biphenyl]-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

1. Kovács T, et al. Sci Rep. 2017 Feb 16;7:42014.

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