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Pimethixene maleate
CAS No. 13187-06-9
Pimethixene maleate( —— )
Catalog No. M33070 CAS No. 13187-06-9
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 73 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePimethixene maleate
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NoteResearch use only, not for human use.
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Brief DescriptionPimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.
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DescriptionPimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorAChR | Histamine Receptor | 5-HT Receptor | Dopamine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number13187-06-9
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Formula Weight409.5
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Molecular FormulaC23H23NO4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (244.20 mM; Ultrasonic )
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SMILESOC(=O)\C=C/C(O)=O.CN1CCC(CC1)=C1c2ccccc2Sc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.?
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