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MK-0249 B
CAS No. 862309-06-6
MK-0249 B( —— )
Catalog No. M33026 CAS No. 862309-06-6
MK-0249 is an orally active, selective and potent histamine H3 receptor antagonist (IC50: 1.7 nM) for the study of attention-deficit and hyperactivity disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 561 | In Stock |
|
| 10MG | 814 | In Stock |
|
| 25MG | 1207 | In Stock |
|
| 50MG | 1572 | In Stock |
|
| 100MG | 2130 | In Stock |
|
| 200MG | 2762 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK-0249 B
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NoteResearch use only, not for human use.
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Brief DescriptionMK-0249 is an orally active, selective and potent histamine H3 receptor antagonist (IC50: 1.7 nM) for the study of attention-deficit and hyperactivity disorders.
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DescriptionMK-0249 (Compound 1) is a potent, selective and orally active histamine H3 receptor antagonist, with anIC50 of 1.7 nM for human H3.
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In VitroMK-0249 (Compound 1) shows very good hepatic clearance values (CLh e 11 mL/min/kg), and is a substrate for rat P-gp but not for human P-gp.MK-0249 displays potent binding affinity to human, rat, and rhesus H3 receptors with Ki values of 6.8 ± 1.3 nM, 33 ± 3 nM, and 4.3 ± 1.2 nM, respectively. MK-0249 shows high intrinsic activity.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorHistamine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number862309-06-6
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Formula Weight431.45
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Molecular FormulaC23H24F3N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (115.89 mM; Ultrasonic )
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SMILESCc1nc2cccc(c2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nagase T, et al. Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists. J Med Chem. 2008 Aug 14;51(15):4780-9.?
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