Cart
sales@molnova.com
MK-0249 B
CAS No. 862309-06-6
MK-0249 B( —— )
Catalog No. M33026 CAS No. 862309-06-6
MK-0249 is an orally active, selective and potent histamine H3 receptor antagonist (IC50: 1.7 nM) for the study of attention-deficit and hyperactivity disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 561 | In Stock |
|
| 10MG | 814 | In Stock |
|
| 25MG | 1207 | In Stock |
|
| 50MG | 1572 | In Stock |
|
| 100MG | 2130 | In Stock |
|
| 200MG | 2762 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMK-0249 B
-
NoteResearch use only, not for human use.
-
Brief DescriptionMK-0249 is an orally active, selective and potent histamine H3 receptor antagonist (IC50: 1.7 nM) for the study of attention-deficit and hyperactivity disorders.
-
DescriptionMK-0249 (Compound 1) is a potent, selective and orally active histamine H3 receptor antagonist, with anIC50 of 1.7 nM for human H3.
-
In VitroMK-0249 (Compound 1) shows very good hepatic clearance values (CLh e 11 mL/min/kg), and is a substrate for rat P-gp but not for human P-gp.MK-0249 displays potent binding affinity to human, rat, and rhesus H3 receptors with Ki values of 6.8 ± 1.3 nM, 33 ± 3 nM, and 4.3 ± 1.2 nM, respectively. MK-0249 shows high intrinsic activity.
-
In Vivo——
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetHistamine Receptor
-
RecptorHistamine Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number862309-06-6
-
Formula Weight431.45
-
Molecular FormulaC23H24F3N3O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (115.89 mM; Ultrasonic )
-
SMILESCc1nc2cccc(c2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1)C(F)(F)F
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Nagase T, et al. Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists. J Med Chem. 2008 Aug 14;51(15):4780-9.?
molnova catalog
related products
-
Pyrogallol
Pyrogallol is a white crystalline powder and a powerful reducing agent prepared by heating gallic acid.
-
Pitolisant hydrochlo...
A potent and selective antagonist of H3 receptor with Ki/EC50 of 0.16/1.5 nM.
-
Ebrotidine
Ebrotidine is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a potent antisecretory activity and evidenced gastroprotection.
