Cart
sales@molnova.com
MC3482 B
CAS No. 2922280-86-0
MC3482 B( —— )
Catalog No. M33011 CAS No. 2922280-86-0
MC3482 is a specific inhibitor of sirtuin5 (SIRT5).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 65 | In Stock |
|
| 5MG | 107 | In Stock |
|
| 10MG | 180 | In Stock |
|
| 25MG | 282 | In Stock |
|
| 50MG | 436 | In Stock |
|
| 100MG | 709 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1423 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMC3482 B
-
NoteResearch use only, not for human use.
-
Brief DescriptionMC3482 is a specific inhibitor of sirtuin5 (SIRT5).
-
DescriptionMC3482 is a specific sirtuin5 (SIRT5) inhibitor.
-
In VitroMC3482 inhibits sirtuin5. 50 μM MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5 intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cells treated with MC3482 and decrease in SIRT5-overexpressing cells.
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorSirtuin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2922280-86-0
-
Formula Weight618.68
-
Molecular FormulaC33H38N4O8
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : ≥ 130 mg/mL (210.12 mM)
-
SMILES[C@H](C(NC1=CC=CC=C1)=O)(NC(OCC2=CC=CC=C2)=O)CCCCNC(CC[C@H](NC(OCC3=CC=CC=C3)=O)C(O)=O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Polletta L, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70.?
molnova catalog
related products
-
Pristimerin
Pristimerin has anticancer activity, treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell characteristics and EMT in cancer cells.
-
UBCS039
UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.
-
MC3482
MC3482 is a potent, specific SIRT5 inhibitor, increases the ammonia content in cells leading to autophagy and mitophagy, shows selective SIRT5 inhibition vs SIRT1-3.
