Malic enzyme inhibitor ME1( —— )

Catalog No. M33006 CAS No. 522649-59-8

Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Malic enzyme inhibitor ME1
Note

Research use only, not for human use.
Brief Description

Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.
Description

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM.
In Vitro

Cell Viability Assay Cell Line:HCT116 and HT29 cell line Concentration:50 μM Incubation Time:72?hours Result:Showed a significant reduction in total cell numbers.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

522649-59-8
Formula Weight

351.4
Molecular Formula

C20H21N3O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (284.58 mM; Ultrasonic (<60°C)
SMILES

Oc1ccc(cc1)N1CCN(CC1)C1CC(=O)N(C1=O)c1ccccc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8.?

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