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I-OMe-Tyrphostin AG 538

CAS No. 1094048-77-7

I-OMe-Tyrphostin AG 538( —— )

Catalog No. M32963 CAS No. 1094048-77-7

I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    I-OMe-Tyrphostin AG 538
  • Note
    Research use only, not for human use.
  • Brief Description
    I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 μM).
  • Description
    I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 μM.
  • In Vitro
    Cell Viability Assay Cell Line:PANC-1 cells Concentration:0.1, 1, 10, 1000 μM Incubation Time:24 hours Result:Cytotoxic to PANC-1 cells in nutrient-deprived medium.Western Blot Analysis Cell Line:PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min) Concentration:0.03, 0.3, 3 μM Incubation Time:1 hour Result:Blocked phosphorylation of IGF-1R, Akt and Erk.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3K | IGF-1R
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1094048-77-7
  • Formula Weight
    437.19
  • Molecular Formula
    C17H12INO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (114.37 mM; Ultrasonic )
  • SMILES
    COc1cc(\C=C(/C#N)C(=O)c2ccc(O)c(O)c2)cc(I)c1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Davis MI, et al. A?homogeneous,?high-throughput?assay?for?phosphatidylinositol?5-phosphate?4-kinase?with a?novel,?rapid?substrate?preparation. PLoS One.?2013;8(1):e54127.?
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