I-OMe-Tyrphostin AG 538

Research use only, not for human use.

I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 μM).

I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 μM.

Cell Viability Assay Cell Line:PANC-1 cells Concentration:0.1, 1, 10, 1000 μM Incubation Time:24 hours Result:Cytotoxic to PANC-1 cells in nutrient-deprived medium.Western Blot Analysis Cell Line:PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min) Concentration:0.03, 0.3, 3 μM Incubation Time:1 hour Result:Blocked phosphorylation of IGF-1R, Akt and Erk.

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PI3K/Akt/mTOR signaling

PI3K

PI3K | IGF-1R

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1094048-77-7

437.19

C17H12INO5

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (114.37 mM; Ultrasonic )

COc1cc(\C=C(/C#N)C(=O)c2ccc(O)c(O)c2)cc(I)c1O

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(-20℃)

With Ice Pack

≥ 2 years