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I-OMe-Tyrphostin AG 538
CAS No. 1094048-77-7
I-OMe-Tyrphostin AG 538( —— )
Catalog No. M32963 CAS No. 1094048-77-7
I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 126 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 432 | In Stock |
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| 50MG | 625 | In Stock |
|
| 100MG | 889 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1786 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameI-OMe-Tyrphostin AG 538
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NoteResearch use only, not for human use.
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Brief DescriptionI-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 μM).
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DescriptionI-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 μM.
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In VitroCell Viability Assay Cell Line:PANC-1 cells Concentration:0.1, 1, 10, 1000 μM Incubation Time:24 hours Result:Cytotoxic to PANC-1 cells in nutrient-deprived medium.Western Blot Analysis Cell Line:PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min) Concentration:0.03, 0.3, 3 μM Incubation Time:1 hour Result:Blocked phosphorylation of IGF-1R, Akt and Erk.
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K | IGF-1R
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Research Area——
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Indication——
Chemical Information
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CAS Number1094048-77-7
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Formula Weight437.19
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Molecular FormulaC17H12INO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (114.37 mM; Ultrasonic )
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SMILESCOc1cc(\C=C(/C#N)C(=O)c2ccc(O)c(O)c2)cc(I)c1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Davis MI, et al. A?homogeneous,?high-throughput?assay?for?phosphatidylinositol?5-phosphate?4-kinase?with a?novel,?rapid?substrate?preparation. PLoS One.?2013;8(1):e54127.?
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