AS-041164

Research use only, not for human use.

AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively).

AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory effects.

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AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema.AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice. The ED50 value for AS-041164 is 27.35 mg/kg. AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation. Animal Model:Male Wistar rats (100-150 g) injected with carrageenan Dosage:10 mg/kg, 30 mg/kg, 100 mg/kg Administration:Oral administration; onceResult:Induced a significant reduction of paw thickness.

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PI3K/Akt/mTOR signaling

PI3K

PI3Kα|PI3Kβ|PI3Kγ|PI3Kδ

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6318-41-8

249.24

C11H7NO4S

>98% (HPLC)

DMSO:125 mg/mL (501.52 mM; Need ultrasonic)

O=C(N1)/C(SC1=O)=C/C2=CC=C3C(OCO3)=C2

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(-20℃)

With Ice Pack

≥ 2 years