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FLT3-IN-4
CAS No. 2304799-09-3
FLT3-IN-4( —— )
Catalog No. M32925 CAS No. 2304799-09-3
FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 249 | In Stock |
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| 5MG | 226 | In Stock |
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| 10MG | 335 | In Stock |
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| 25MG | 539 | In Stock |
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| 50MG | 714 | In Stock |
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| 100MG | 918 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1841 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFLT3-IN-4
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NoteResearch use only, not for human use.
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Brief DescriptionFLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia.
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DescriptionFLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor for treating acute myelogenous leukemia.
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In VitroFLT3-IN-4 (Compound 9u) shows potent inhibitory activities against MV4-11 and Molm-13 cells with IC50 values are 0.089±0.001 nM and 0.022±0.003 nM, respectively.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetFLT
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RecptorFLT
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Research Area——
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Indication——
Chemical Information
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CAS Number2304799-09-3
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Formula Weight431.49
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Molecular FormulaC23H25N7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (57.94 mM; Ultrasonic )
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SMILESCC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn(CC=C)c3ncnc(N)c23)no1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yuan X, et al. Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. J Med Chem. 2019 Apr 25;62(8):4158-4173.?
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