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JAK3-IN-14
CAS No. 454234-24-3
JAK3-IN-14( —— )
Catalog No. M35961 CAS No. 454234-24-3
JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ～40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 344 | Get Quote |
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| 5MG | 620 | Get Quote |
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| 10MG | 904 | Get Quote |
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| 25MG | 1279 | Get Quote |
|
| 50MG | 1730 | Get Quote |
|
| 100MG | 2304 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameJAK3-IN-14
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NoteResearch use only, not for human use.
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Brief DescriptionJAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ～40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.
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DescriptionJAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetFLT
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RecptorFLT
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Research Area——
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Indication——
Chemical Information
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CAS Number454234-24-3
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Formula Weight287.32
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Molecular FormulaC18H13N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (435.05 mM; Ultrasonic )
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SMILESC(=C1C=2C(NC1=O)=CC=C(C2)C=3C=CC=NC3)C4=CC=CN4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen JJ, et al. Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5633-8.?
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