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DHODH-IN-12
CAS No. 1263303-93-0
DHODH-IN-12( —— )
Catalog No. M32884 CAS No. 1263303-93-0
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 124 | In Stock |
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| 5MG | 153 | In Stock |
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| 10MG | 225 | In Stock |
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| 25MG | 337 | In Stock |
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| 50MG | 462 | In Stock |
|
| 100MG | 631 | In Stock |
|
| 200MG | 851 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDHODH-IN-12
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NoteResearch use only, not for human use.
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Brief DescriptionDHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
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DescriptionDHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of5.07.
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In VitroDesigned a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorDehydrogenase
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Research Area——
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Indication——
Chemical Information
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CAS Number1263303-93-0
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Formula Weight203.2
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Molecular FormulaC10H9N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C(/C(/C#N)=N/O)=O)C1=CC=C(C)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.?
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