CFTR corrector 4

Research use only, not for human use.

CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer.

CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis.

CFTR corrector 4 possesses high potency and efficacy with a EC50 of 0.028 μM in this HBE-TECC assay that assess the CFTR function, this lead resides in undesirable drug-like space with high molecular weight, and high HPLC Log?D, indicating high lipophilicity. HBE-TECC: (Human?Bronchial?Epithelial-Trans-Epithelial?Current?Clamp) assay.CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with a EC50 value 130 nM in the cell surface expression (CSE-HRP) assay.

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Apoptosis

CFTR

CFTR

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1918142-34-3

539.52

C29H27F2NO7

>98% (HPLC)

In Vitro:?DMSO : 110 mg/mL (203.88 mM; Ultrasonic )

COc1ccc2[C@@H](C[C@@H](Oc2c1)c1ccc(OC)c(OC)c1)NC(=O)C1(CC1)c1ccc2OC(F)(F)Oc2c1

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(-20℃)

With Ice Pack

≥ 2 years