PPQ-102( CFTR Inhibitor IV | Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV )

Catalog No. M16668 CAS No. 931706-15-9

COA

Datasheet

HNMR

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Product Name

PPQ-102
Note

Research use only, not for human use.
Brief Description

PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
Description

PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
In Vitro

Cell Viability Assay Cell Line:E13.5 embryonic kidneys (embryonic kidney organ culture model of PKD)Concentration:0, 0.5, 5 μM Incubation Time:3 or 4 days Result:Remarkablyreduced the number and size of renal cysts formed in the 8-Br-cAMP-containing medium (showed ～60% inhibition of cyst formation at 0.5 μM, near complete absence of cysts at 2.5 and 5 μM).Remarkable reduced cyst size over 1 and 2 days in the 8-Br-cAMP-containing medium.
In Vivo

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Synonyms

CFTR Inhibitor IV | Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
Pathway

Apoptosis
Target

CFTR
Recptor

CFTR
Research Area

Other Indications
Indication

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CAS Number

931706-15-9
Formula Weight

438.48
Molecular Formula

C26H22N4O3
Purity

>98% (HPLC)
Solubility

DMSO: 5 mg/mL
SMILES

O=C1N(C)C(C(C(N1C)=O)=C2C3=CC=CC=C3)=C4N2C5=C(C=CC=C5)NC4C6=CC=C(C)O6
Chemical Name

7,9-dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-dione

1.Tradtrantip L, et al. J Med Chem. 2009 Oct 22;52(20):6447-55.

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