Benzcyclane( —— )

Catalog No. M32802 CAS No. 2179-37-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Benzcyclane
Note

Research use only, not for human use.
Brief Description

Benzcyclane (Benzcyclan) is an inhibitor of platelet aggregation and also a vasodilator that can be used in a variety of peripheral circulation disorders.
Description

Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation inhibitor and a vasodilator effective in a variety of peripheral circulation disorders.
In Vitro

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In Vivo

Benzcyclane, although capable of aggregating platelets by itself at very high concentrations, shows a striking inhibitory effect, over a wide range of concentrations, both on platelet aggregation induced by ADP, epinephrine or collagen and on platelet adhesiveness to glass or collagen. Clot retraction is also clearly inhibited. Benzcyclane induces use-dependent inhibition of Na channels in muscle, similarly as do class 1 antiarrhytnmic drugs. Inhibition was observed with both normal and cevadine-modified Na channels.
Synonyms

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Pathway

Others
Target

Platelet aggregation
Recptor

Platelet aggregation
Research Area

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Indication

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1. Ponari O, et al. In vitro effects of bencyclan on coagulation, fibrinolysis and platelet function. Arzneimittelforschung. 1976;26(8):1532-8.?

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