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BCI hydrochloride

CAS No. 95130-23-7

BCI hydrochloride( —— )

Catalog No. M32799 CAS No. 95130-23-7

BCI hydrochloride ((E)-BCI hydrochloride) is a selective dual-specificity phosphatase 6 (DUSP6) inhibitor that inhibits RANKL-mediated osteoclastogenesis and attenuates oophorectomy-induced bone loss.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BCI hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    BCI hydrochloride ((E)-BCI hydrochloride) is a selective dual-specificity phosphatase 6 (DUSP6) inhibitor that inhibits RANKL-mediated osteoclastogenesis and attenuates oophorectomy-induced bone loss.
  • Description
    BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research.
  • In Vitro
    Western Blot Analysis Cell Line:RAW264.7 macrophage cells Concentration:100 ng/mL Incubation Time:24 hours Result:Showed DUSP6 protein down regulation.RT-PCR Cell Line:RAW264.7 macrophage cells Concentration:0-1 nM Incubation Time:24 hours Result:Inhibited the expression of IL-1β and IL-6 mRNA in LPS-activated macrophages.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    Phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    95130-23-7
  • Formula Weight
    353.89
  • Molecular Formula
    C22H24ClNO
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 15.62 mg/mL (44.14 mM; Ultrasonic )
  • SMILES
    Cl.O=C1C=2C=CC=CC2C(NC3CCCCC3)C1=CC=4C=CC=CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.?
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