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Tuvusertib
CAS No. 1613200-51-3
Tuvusertib( —— )
Catalog No. M32792 CAS No. 1613200-51-3
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 μΜ) with selective and potentially antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 145 | In Stock |
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| 5MG | 126 | In Stock |
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| 10MG | 198 | In Stock |
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| 25MG | 383 | In Stock |
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| 50MG | 523 | In Stock |
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| 100MG | 741 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTuvusertib
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NoteResearch use only, not for human use.
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Brief DescriptionTuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 μΜ) with selective and potentially antitumor activity.
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DescriptionTuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ.
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In VitroWestern Blot Analysis Cell Line:U266 and OPM2 cells Concentration:0-2 μM Incubation Time:24 h Result:Increased level of γH2A.X, cleavage of caspase-3, and cleavage of PARP.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetChk
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RecptorChk | ATM/ATR | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1613200-51-3
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Formula Weight370.32
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Molecular FormulaC16H12F2N8O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (13.50 mM; Ultrasonic )
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SMILESCn1cncc1-c1c(F)cncc1NC(=O)c1c(N)nn2cc(F)cnc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nadia AHMAD, et al. Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof. WO2015187451A1
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