Tumulosic acid( —— )

Catalog No. M32345 CAS No. 508-24-7

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HNMR

HPLC

MSDS

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Product Name

Tumulosic acid
Note

Research use only, not for human use.
Brief Description

Tumulosic acid is a natural product for research related to life sciences.
Description

Tumulosic acid is a natural product for research related to life sciences.
In Vitro

Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM).Tumulosic acid decreases in LL-37 production in human keratinocytes. Tumulosic acidshows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM). Western Blot Analysis Cell Line:Normal human epidermal keratinocytes (NHEKs) Concentration:1 μM and 10 μM Incubation Time:23 h in the presence of 10 μM cycloheximide Result:Decreased LL-37 production in epidermal keratinocytes.
In Vivo

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