3,4,7-Trihydroxyisoflavone( —— )

Catalog No. M32122 CAS No. 485-63-2

COA

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HNMR

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Product Name

3,4,7-Trihydroxyisoflavone
Note

Research use only, not for human use.
Brief Description

3',4',7-Trihydroxyisoflavone is a natural product.
Description

3',4',7-Trihydroxyisoflavone is a natural product.
In Vitro

7,3',4'-Trihydroxyisoflavone triggers cell cycle arrest at the G1 phase and displays an anti-proliferative effect against EGF receptor-positive skin cancer. 7,3',4'-Trihydroxyisoflavone also significantly inhibits UVB-induced COX-2 expression by suppressing the NF-B transcription activity in mouse skin epidermal JB6 P+ cells.
In Vivo

In a mouse skin tumorigenesis model, 7,3',4'-Trihydroxyisoflavone strongly suppresses the incidence, multiplicity, and volume of UVB-induced mouse skin tumors. Consistent with the tumor data, 7,3',4'-Trihydroxyisoflavone clearly attenuates UVB-induced COX-2 expression in hairless mouse skin.
Synonyms

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Target

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Recptor

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Research Area

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